Abstract
The paper by Hliniak et al (1983) regarding the influence of dose upon the local control of skin cancer illustrates the pit which has befallen many radiotherapists even back to Strandqvist (1944). Although the present investigators have analysed the incidence of failures of radiotherapy for skin cancer also by field size (thus, indirectly, by tumour volume) they do not consider the bias in favour of short fraction numbers for smaller tumours in their data. Thus the iso-effect slope derived from their dose/fraction data is also biased in the direction of a steeper slope than would exist if equally sized tumours were treated uniformly through the fraction number spectrum.
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