Abstract
Coagulation factor VII (FVII), a vitamin K-dependent serine protease, is essential in the initiation phase of the coagulation cascade. The circulating FVII zymogen binds to tissue factor (TF) and is thereafter rapidly activated to FVIIa, enhancing the enzymatic activity dramatically [ [1] McVey J.H. Boswell E. Mumford A.D. Kemball-Cook G. Tuddenham E.G. Factor VII deficiency and the FVII mutation database. Human Mutat. 2001; 17: 3-17 Crossref PubMed Scopus (147) Google Scholar ]. Increased plasma levels of FVII have, in several studies, been suggested as a risk factor for coronary heart disease [ 2 Meade T.W. Mellows S. Brozovic M. Miller G.J. Chakrabarti R.R. North W.R. et al. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park heart study. Lancet. 1986; 2: 533-537 Abstract PubMed Scopus (1903) Google Scholar , 3 Miller G.J. Bauer K.A. Barzegar S. Cooper J.A. Rosenberg R.D. Increased activation of the haemostatic system in men at high risk of fatal coronary heart disease. Thromb. Haemost. 1996; 75: 767-771 Crossref PubMed Scopus (178) Google Scholar ].
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