Abstract
Chromosome aberrations were scored in V-79 strain Chinese hamster cells grown in vitro. The percent of aberrant mitoses observed in anaphase and early telophase increased significantly with temperature over the range of values between 35° and 40°C. No significant increase in aberration percentage was observed when the culture growth time was extended from 2 to 3 days. The progressive increase in chromosome damage with temperature supports the concept that genetic information is thermally degraded even at temperatures in the normal physiological range. Since an increase in chromosome aberration frequency is correlated with aging, it may be that thermally induced information loss is an important factor in the aging process. However, the dependence of the aberration percentage on temperature is not sufficiently strong to fully explain the thermal loss of proliferative capacity of cells in culture. Additional temperature-dependent processes must occur and may further contribute to the thermal destruction of cellular information.
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