Abstract
The aim of this study was to investigate the effect of zinc supplementation (in the form of nano or microparticles) on the profile and metabolism of fatty acids in the liver microsomes of rats with induced breast cancer. The activity of desaturases (Δ5, Δ6, Δ9) and the level of cholesterol and its oxidized derivatives were measured. The aim of this study was also to determine the effect of various forms of zinc supplements on rats that were on 5-, 12- and 15-hydroxyeicosatetraenoic (5-, 12- and 15-HETE) and hydroxyoctadecadienoic (HODE) acids, and the level of prostaglandin E2 (PGE2). Female Spraque-Dawley rats (n = 24) were divided into 2 groups that were supplemented with zinc in the micro form (342 nm) or nano form (99 nm) particles, respectively, and a group with a standard diet (control group). All animals received 7,12-dimethylbenz[a]anthracene twice for the induction of breast cancer. Dietary nano-Zn supplementation increased vaccenic acid content (p = 0.032) and decreased Δ6-desaturase activity (p = 0.006), whereas micro-Zn increased cholesterol (p = 0.006), ∑COPs (total cholesterol-oxidation products) (p = 0.019) and PGE2 (p = 0.028) content. Dietary enrichment with Zn microparticles resulted in lower concentrations of the metabolites 15-, 12- and 5-HETE and HODE. Our study indicates that the effect of zinc supplementation on the metabolism of fatty acids in the liver microsomes under neoplastic conditions depends on the form in which it is administered.
Highlights
Published: 27 October 2021Currently, cancer is both a huge health and social problem worldwide
eicosapentaenoic acid (EPA) metaboare derivatives of arachidonic acid (15-hydroxyeicosatetraenoic acids (HETE), 12-HETE and 5-HETE), lino lites were undetectable, so we focused on only four compounds
Our study is the first to show that the effect of zinc supplementation under tumor process conditions on fatty acid metabolism in the liver depends on the form in which it is administered
Summary
Cancer is both a huge health and social problem worldwide. It is estimated to be responsible for one in six deaths worldwide [1]. In 2021, the World Health Organization (WHO) announced that the most commonly diagnosed cancer is no longer lung cancer, but breast cancer [1]. It is diagnosed in 12% of women within a year. Over the past 20 years, the total number of breast cancers in the world has increased by almost. In 2020, the disease was diagnosed in 2.3 million women [1]. The search for effective methods of diagnosis and treatment, as well as compounds with potential anti-cancer activity, is still ongoing
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
