Abstract
This present study aimed to assess the influence of different chemical compounds which are commonly found in the composition of products used for oral hygiene on primary gingival keratinocyte, human gingival fibroblast and tongue squamous cell carcinoma behaviour. Chlorhexidine (Chx), aspartame (Asp), xylitol (Xyl) and sodium bicarbonate (NaB) were evaluated in an in vitroresearch regarding cells morphology and cytotoxicity. Primary gingival keratinocytes (PGK)and fibroblasts (HGF)treated with different concentration of the tested compounds did not show significant changes, nor related to morphology nor related to viability at the lowest concentrations used ([ 25�M). In contrast, the tumor cells were affected by the test compounds, especially xylitol and sodium bicarbonate, both in terms of morphology and cytotoxicity, at concentrations over 5�M.
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