Abstract
In vitro experiments were performed on mouse spleen cells to establish possible influences of some naturally occurring prostaglandins on DNA synthesis and DNA excision repair. The prostaglandins A 1, B 1, E 1, E 2 and F 2 were tested in concentrations of lopg, 5ng and 2.5μg per ml cell suspension. DNA synthesis was significantly increased by pgF 2α in all the three concentrations tested, while the other tested prostaglandins were essentially ineffective. DNA excision repair was significantly inhibited by PgF 1 and PgF 2 at 5ng/'ml and at 2.5μg/ml but increased by PgF 2α in the two lower concentrations. The rejoining of DNA-strand breaks after γ-irradiation was slightly reduced by PgF 1, PgE 2 and PgF 2α at 2.5μg/ml.
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