Abstract
The Influence of Some Irritant Chemicals and Scarification on Tumour Initiation by Urethane in Mice
Highlights
WHEN mice were injected with urethane and the skin of the back subsequently painted once each seventb day for twenty weeks with croton oil as a promoting agent, the number of papiRomata produced was found to be increased if the mice were given a preliminary apphcation of croton ofl, dissolved in acetone, to the area at 18, 24 or 48 hours preceding the injection of urethane (Pound and Ben, 1962)
To consider whether the augmenting influence of a preliminary apphcation of croton oil was associated with croton oil specificauy, in particular with its action as a promoter, or was an effect that could be elicited by any other substance or means that produced inflammation or ceRular proliferation in the skin
The augmenting influence of a solution of croton oil in acetone has been ascribed in previous work to the croton oil (Pound and Bell, 1962 ; Pound, 1963) so that data are presented formaRy proving that the acetone solvent has an insignificant influence in this respect
Summary
WHEN mice were injected with urethane and the skin of the back subsequently painted once each seventb day for twenty weeks with croton oil as a promoting agent, the number of papiRomata produced was found to be increased if the mice were given a preliminary apphcation of croton ofl, dissolved in acetone, to the area at 18, 24 or 48 hours preceding the injection of urethane (Pound and Ben, 1962). This was due to local phenomena produced in the skin by the prehminary application of croton oil (Pound, 1963). The augmenting influence of a solution of croton oil in acetone has been ascribed in previous work to the croton oil (Pound and Bell, 1962 ; Pound, 1963) so that data are presented formaRy proving that the acetone solvent has an insignificant influence in this respect
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