Abstract
Introduction: With the arrival of the SARS-CoV-2 (Coronavirus 2 of severe acute respiratory syndrome) pandemic in Brazil, especially in the city of São Paulo, there was a need to apply social isolation policies associated with testing, covering all municipalities. The Clinical Analysis Laboratory of Centro Universitário FMABC was one of the first laboratories to receive certification and qualification to perform RT-PCR (reverse transcriptase reaction followed by polymerase chain reaction) tests in the metropolitan region of São Paulo.
 Objective: Aim to analyze the influence of adopting social isolation on the incidence of positivity in COVID-19 tests in the metropolitan region of São Paulo, Brazil.
 Methods: a descriptive study carried out from March to May 2020, epidemiological data were collected from each unit served and organized by the data controllership team of the Clinical Analysis Laboratory of FMABC. Epidemiological, demographic, and laboratory data were extracted from the Matrix® outpatient data management system. Clinically suspected cases and confirmed by laboratory tests (RT-PCR and serological tests) were entered. The tests were divided into serological tests using the RT-PCR molecular test, on samples of nasopharyngeal mucosal scrapings collected with sterile Swab.
 Results: It were evaluated PCR test and antibody presence (IgA, IgM and IgG) in blood samples of 16.297 patients. 22.718 tests were performed for the diagnosis of COVID-19, both RT-PCR (10.410 tests) and serological tests to detect anti-SARS-CoV-2 antibodies, IgA, IgM and IgG, a total of 16.297 patients were assessed, 63% women and 37% men. It was observed that the social isolation policies adopted during this period contained the massive expansion of contamination, at least while the social isolation rates were above 55%.
 Conclusion: The data of this study demonstrated the effectiveness of social isolation in containing the positive contamination of SARS-CoV-2 in the metropolitan region of São Paulo, at least for the first three months.
Highlights
With the arrival of the SARS-CoV-2 (Coronavirus 2 of severe acute respiratory syndrome) pandemic in Brazil, especially in the city of São Paulo, there was a need to apply social isolation policies associated with testing, covering all municipalities
The data of this study demonstrated the effectiveness of social isolation in containing the positive contamination of SARSCoV-2 in the metropolitan region of São Paulo, at least for the first three months
The intervention non-pharmacological to combat COVID-19 are widely used around the world and promote better performance in flattening the COVID-19 pandemic curve of social distancing is effective as a public health measure with individual, environmental and community reach, promoting the isolation of cases, reduced contact between individuals and a reduction in the number of deaths related to COVID-194
Summary
With the arrival of the SARS-CoV-2 (Coronavirus 2 of severe acute respiratory syndrome) pandemic in Brazil, especially in the city of São Paulo, there was a need to apply social isolation policies associated with testing, covering all municipalities. In late November 2019, a new disease caused by coronavirus-2 (SARS-CoV-2) appeared in Wuhan, China Infection with this new coronavirus results COVID-19, an acute respiratory syndrome with approximately 4% lethality[1,2]. This social distance is one of the preventive measures to control the extensive dissemination of COVID-19 These measures of social distancing, as a non-pharmacological intervention to combat COVID-19, are widely used around the world and promote better performance in flattening the COVID-19 pandemic curve. The intervention non-pharmacological to combat COVID-19 are widely used around the world and promote better performance in flattening the COVID-19 pandemic curve of social distancing is effective as a public health measure with individual, environmental and community reach, promoting the isolation of cases, reduced contact between individuals and a reduction in the number of deaths related to COVID-194
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