Abstract
This study attempted to verify the effects of <i>Lentinus edodes</i>mycelium by applying a high-fat diet (HFD) to animals. For this, the <i>Lentinus edodes</i>mycelium ‘MC-LE’ was administered to the HFD animals, investigating its influence on dietary efficiency, hormones, blood and lipocytes. An experiment was performed a normal group with regular diet, HFD/Control group and HFD/MC-LE (360 mg/kg) group over 10 weeks. Compared to the HFD/Control group, the HFD/MC-LE group revealed a decrease in dietary efficiency. A significant drop was also found in the appetite-suppressing hormone ‘leptin’. Furthermore, increase in the adipose (fat) accumulationrelated adiponectin and decrease in IGF-1, glucose and free fatty acid accelerated lipid metabolism, confirming inhibition of fat accumulation through the size and number of fat cells. Other words, in the HFD/MC-LE group, dietary control hormone suppressed diet and accelerated lipid metabolism, reducing fat accumulation. The above results confirm that the <i>Lentinus edodes</i>mycelium ‘MC-LE’ would be useful as a material for obesity treatment.
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