Abstract
Background: Cardiac resynchronization therapy (CRT) is an established therapy for end-stage heart failure. It is currently recommended to position the left ventricular (LV) lead at the postero-lateral (PL) wall. However, the position of the right ventricular (RV) lead remains controversial, since it may be associated with adverse hemodynamic effects. This may partly explain non-response to CRT. We hypothesized that RV pacing during biventricular pacing signiicantly modulates response. We studied the acute invasive hemodynamic response of RV, LV and biventricular pacing.
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