Abstract
1092 Background: Sleep disturbances are distressing and common among breast cancer patients during treatment. However, few studies have examined the impact of radiotherapy (RT) on sleep quality. The goal of this study was to prospectively assess breast cancer patients before, during, and after RT to determine the impact of RT on sleep. Methods: Following breast conserving surgery, 80 breast cancer patients were enrolled on a prospective, longitudinal study of sleep before, during, and after whole breast RT. All patients received a dose of 50 Gy followed by a 10 Gy boost. Subjects completed the Pittsburgh Sleep Quality Index (PSQI) before (i.e., baseline), at week 6 of RT, and 6 weeks after RT completion. Demographic, patient- and treatment-related factors were also recorded. Paired t tests were used to test longitudinal differences in PSQI between time points. Linear mixed models were used to identify predictors of higher PSQI scores and poor sleep (i.e., PSQI score >5). Results: Before, during, and after...
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