The influence of radiation the quality
 of life assessment in patients
 with metastatic brain lesions

Abstract

Relevance: Metastatic brain lesion (MBL) is a serious complication of the course of cancer. The advances in medicinal
 treatment have increased patients’ overall survival and, thereby, the MBL frequency. On the other hand, opportunities for the
 treatment of patients with MBL are expanding. Microsurgical techniques, stereotactic radiation therapy, and radiosurgery are
 actively implemented. Effective therapy and local control of MBL are of paramount importance for the prognosis and quality
 of life (QOL) of patients.
 This study aimed to investigate the influence of radiation therapy on quality of life assessment in patients with metastatic
 brain lesions.
 Results: The QOL analysis of patients with MBL showed that QOL mainly depends on the localization, histo-biological properties of the tumor, the severity of preoperative neurological deficit, as well as age and gender. MBL control may be important
 for maintaining the patient’s QOL but does not always affect survival, which is determined by the activity and prevalence of
 the disease.
 Conclusion: The QOL of patients with MBL is the defining criterion for assessing their condition and the effect of the therapy. This is because the limitations of the normal existence of the patient arising from a chronic disease are often more important to the patient than the symptoms of the disease.