Abstract
The gastric emptying of two radiolabelled antacid preparations has been monitored by gamma scintigraphy with subjects in 3 postures: supine, lying on their left sides and lying on their right sides. Aluminium hydroxide- and alginate-based formulations have been radiolabelled with indium-113m and administered to healthy volunteers following a liquid meal. The antacid containing aluminium hydroxide mixed and emptied with the other stomach contents. The raft-forming alginate formulation emptied faster than the food in subjects lying on their left sides, and slower in subjects lying on their right sides. Thus the protection afforded by alginate-based preparations in the treatment of oesophageal reflux may be strongly influenced by posture.
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