Abstract
Background: Blood rheology abnormalities are recognized as one of the main pathophysiological components of bronchial asthma. Standard medical treatment of bronchial asthma does not exert any substantial effect on blood fluidity. Aim: To assess efficacy of quantum haemotherapy and its influence on blood rheology in the combination treatment of bronchial asthma. Materials and methods: Four hundred and eighty patients admitted to our in-patient department with mild (44.5%) and severe (55.5%) exacerbations of persistent moderate asthma, were randomized into two groups: the main group (n = 250), which, along with conventional treatment, received photohaemotherapy with blue (PHB, n = 220) or red (PHR, n = 30) light, and the control group (n = 230), which received conventional treatment for two weeks. PHB (light-emitting diode devise “Solaris”) and PHR (helium neon laser) was performed according to the following regimen: duration of a session 30 minutes, number of sessions, from 5 to 7 with in-between intervals of 2 to 3 days. The degree of erythrocyte deformation, relative membrane charge and relative gradient membrane potential of erythrocytes, total erythrocyte counts, hemoglobin levels, hematocrit, and blood viscosity were assessed at days 1 and 14, as well as after 3 months. Results: At day 14, the relative gradient membrane potential of erythrocytes decreased to 0.118 ± 0.01 r.u. in the PHB group, to 0.167 ± 0.01 r.u. in the PHR group, and to 0.153 ± 0.01 r.u. in the conventional treatment group. The relative charge of erythrocyte membranes increased to 0.202 ± 0.07, 0.19 ± 0.07 and 0.14 ± 0.07 r.u., the degree of erythrocyte deformation decreased to 1.4 ± 0.1, 1.6 ± 0.1 and 1.9 ± 0.1 scores, the degree of hypoxic anisotropy of the serum decreased to 0.8, 0.9 and 1.2 scores, respectively (in all cases, p 0.05). At month 3, all patients, despite their clinical well-being, demonstrated a deterioration of the parameters studies. However, only in the conventionally treated group the degree of this deterioration was compatible with parameters registered during an asthma exacerbation. Conclusion: Blood rheology parameters demonstrated a more rapid and advanced improvement in patients with exacerbations of bronchial asthma, who were treated with the use of photohaemotherapy, compared to those who received conventional treatment only.
Highlights
Blood rheology abnormalities are recognized as one of the main pathophysiological components of bronchial asthma
В свою очередь, эта группа была разделена на две подгруппы: в 1-ю вошли 220 пациентов, получавших лечение методом фотогемотерапии с использованием синего света (ФГТ СС, светодиодный аппарат Соларис), во 2-ю – 30 больных, у которых применяли фотогемотерапию красным светом (ФГТ КС, гелий-неоновый лазер)
Blood rheology parameters demonstrated a more rapid and advanced improvement in patients with exacerbations of bronchial asthma, who were treated with the use of photohaemotherapy, compared to those who received conventional treatment only
Summary
По единому протоколу открытого сравнительного проспективного рандомизированного исследования обследованы 480 больных с обострением персистирующей бронхиальной астмы средней тяжести: из них у 44,5% было легкое обострение, у 55,5% – тяжелое. У которых проводилось комплексное лечение обострений бронхиальной астмы с использованием фотогемотерапии, включала 250 пациентов. В свою очередь, эта группа была разделена на две подгруппы: в 1-ю вошли 220 пациентов, получавших лечение методом фотогемотерапии с использованием синего света (ФГТ СС, светодиодный аппарат Соларис), во 2-ю – 30 больных, у которых применяли фотогемотерапию красным светом (ФГТ КС, гелий-неоновый лазер). Контрольную группу составили 230 пациентов, получавших в течение 2 недель стандартную терапию обострений бронхиальной астмы. В процессе исследования (при поступлении, на 14-й день и через 3 месяца наблюдения) оценивались степень деформации эритроцитов (СДЭ), относительный заряд мембраны (ОЗМЭ) и относительный градиентный мембранный потенциал (ОГМП) эритроцитов, общее количество эритроцитов (× 10/л), уровень гемоглобина (Hb, г/л), вязкость крови (мПа·с), гематокрит (Ht, %). Изменения биофизических показателей крови у больных бронхиальной астмой, получавших стандартную терапию в сочетании с фотогемотерапией синим светом
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
