Abstract
The first-order hydrolysis kinetics of cefetamet pivoxil (CP) were investigated as a function of pH, temperature and buffers. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH–rate profiles for hydrolysis of cefetamet pivoxil were obtained at 333, 343, 353 and 363 K. The pH–rate expression was k pH= k H + a H + + k H 2O k OH − a OH − , where k H + and k OH − are the second-order rate constants (mol −1 l s −1) for hydrogen ion activity and for hydroxyl ion activity respectively, and k H 2O is the pseudo-first-order rate constant (s −1) for spontaneous reaction under the influence of water. The pH–rate profile was characteristically U-shaped. Maximum stability was observed in the pH region from 3 to 5.
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