Abstract
The influence of pH on the complex formation of phosphoethanolamine and pyrimidine nucleosides (uridine, cytidine and thymidine) with copper(II) ions was studied. All investigations were performed in aqueous solution. The overall stability constants of the complexes and non-covalent compounds were obtained using the potentiometric method with computer calculation of the data. Moreover, equilibrium constants of the reaction were determined. The mode of coordination was obtained using spectroscopic methods. Analysis of the potentiometric and spectroscopic data confirmed the involvement and effectiveness of phosphate groups in species formation as well as the influence of pH on the mode of coordination of the investigated biomaterials. In the next step, studied complexes will be applied as potential biomaterials with biological applications.
Highlights
Faculty of Chemistry, Adam Mickiewicz University in Poznan, Uniwersytetu Poznanskiego 8, Pharmaceutical Sciences Department, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; Abstract: The influence of pH on the complex formation of phosphoethanolamine and pyrimidine nucleosides with copper(II) ions was studied
Other compounds found in organisms containing a phosphate group are phosphoserine, phosphothreonine, phosphocholine and phosphoethanolamine
It was proved that the effect of meclizine on cellular respiration was enhanced by ethanolamine
Summary
Faculty of Chemistry, Adam Mickiewicz University in Poznan, Uniwersytetu Poznanskiego 8, Pharmaceutical Sciences Department, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; Abstract: The influence of pH on the complex formation of phosphoethanolamine and pyrimidine nucleosides (uridine, cytidine and thymidine) with copper(II) ions was studied. The overall stability constants of the complexes and noncovalent compounds were obtained using the potentiometric method with computer calculation of the data. Analysis of the potentiometric and spectroscopic data confirmed the involvement and effectiveness of phosphate groups in species formation as well as the influence of pH on the mode of coordination of the investigated biomaterials. The potential non-covalent interactions and metal ion bonding is the donor nitrogen atoms N(3), and phosphate groups for nucleotides. Other compounds found in organisms containing a phosphate group are phosphoserine, phosphothreonine, phosphocholine and phosphoethanolamine. Phospholipids like PE play an important role in living organisms because they are structural and functional components of biomembranes and play a dynamic role in regulatory processes [7,8,9,10,11]. Copper(II) proteins have diverse roles in biological electron transfer and oxygen
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