Abstract
To determine whether HCG administration during the luteal phase will counteract the “luteolytic” effects of oxymetholone in humans (shortening of luteal phase length and decrease of blood progesterone), five women were studied during a total of 15 cycles. Blood progesterone levels were estimated during treatment with oxymetholone only, with HCG only, and with HCG employed simultaneously with oxymetholone. In the presence of HCG, oxymetholone did not evoke precipitous menstrual bleeding; on the contrary, the luteal phase length was extended in the same way as with HCG treatment only. The ovarian progesterone output was increased: by an average of 70 percent over the control values, and by an average of 105 percent over values in the cycles with oxymetholone treatment only. It is concluded that although oxymetholone interferes with the corpus luteum function of the normal luteal phase, this action is insufficient to interfere with the HCG stimulated corpus luteum. It is suggested that the HCG test be performed with compounds designated for post-conceptional fertility control.
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