Abstract
Fourteen children and adolescents (12 males and 2 females) aged from 7 6/12 to 18 6/12 years underwent an oral glucose tolerance test (OGTT 1.75 g/kg) followed at 180 min by i.v. glucagon injection (0.03 mg/kg). On a separate occasion these children underwent a simple i.v. glucagon test. Combining the glucose and insulin response in the two glucagon tests for each child we found that whereas in the single test the blood glucose rose slowly with a peak at 39 min, in the combined test the peak was at 5 min. The mean peak values were similar (129 and 121 mg%). The mean peak insulin response in the single test was 79 mIU/ml (at 2 min) as compared to 253 mIU/ml (at 2 min ) in the combined test. Our studies provide further evidence for a direct effect of glucagon on insulin release and that glucose preloading augments this effect, without relation to the blood glucose concentrations.Established Investigator of The Chief Scientist's Bureau of Health
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