THE INFLUENCE OF OBESITY ON INTERRELATION BETWEEN ADROPIN AND PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS

Abstract

Objective: The pulse wave velocity (PWV) is one of the most important marker of the hypertensive patient's state. The adropin levels is diminished in patients with essential hypertension, but it is not investigated the association between this peptide and pulse wave velocity in hypertensive patients and in hypertensive patients under the influence of concomitant obesity. The objective was to investigate the influence of concomitant obesity on the interrelation between adropin level and PWV in hypertensive patients. Design and method: 93 patients were under supervision in our study, 63 females, and average age 57.8 ± 8.3 years. 47 patients with essential hypertension associated with obesity formed the first group and 46 subjects of the second group had only hypertension. ELISA was used to measure the serum level of adropin. We used the applanation tonometry to estimate the carotid-femoral PWV. Obesity was considered as body mass index over 30 kg/m2. Results: The mean serum adropin level and PWV levels were 2.75 [2.08–4.21] pg / ml, 9.71 [7.01–10.36] m/s, in the first group and 3.51 [2.47–3.91] pg/ml, 8.53 [6.73–9.74] m/s in the second group respectively. There were significant differences between the groups in both adropin level and PWV (p < 0.01). The multivariate regression analysis did not showed that low adropin level was associated with increased values of PWV (p = 0.09) in hypertensive patients with concomitant obesity. In contrast, it was revealed significant association between PWV and adropin in the second group - (odds ratio 0.41, 95% confidence interval 0.021–0.64, p = 0.003). Conclusions: Conclusions: It was found that the presence of additional comorbid obesity in hypertensive patients lead to perversion of adropin and PWV interrelation. In obese hypertensive patients adropin did not evince its predictive role in PWV value but, in contrast, in hypertensive patients without obesity adropin is associated significantly with PWV, but further studies with larger amount of patients are needed to confirm these findings.