Abstract
Abstract The urinary excretion of tryptophan metabolites was studied in 10 patients with Hodgkin's disease. As previously found, kynurenine, 3-hydroxykynurenine and 3-hydroxyanthranilic acid were spontaneously excreted in abnormally high amounts, appearing to be a constant characteristic in patients with Hodgkin's disease. Tryptophan loading produced an abnormal excretion of 10 metabolites in all, and normal excretion was only partially restored by treatment with nicotinamide administration before a second tryptophan test in the same patients. The effect of nicotinamide on the excretion pattern appeared to differ qualitatively and quantitatively from that obtained using vitamin B6 administration. These data show the existence, in Hodgkin's disease, of a deficiency of nicotinamide-dependent enzymes acting on the tryptophan → nicotinic acid pathway, besides that correlated to vitamin B6.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Clinica chimica acta; international journal of clinical chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
