Abstract

Lipid droplets are intracellular storage organelles for neutral lipids, such as triacylglycerols and sterol esters. They are surrounded by a phospholipid monolayer that embeds and associates with different proteins during the lipid droplet lifecycle. Recent experiments have shown that protein recruitment can change depending on the composition of the neutral core. Moreover, sterol-rich lipid droplets have been shown to undergo a phase change to an ordered liquid-crystalline smectic phase with concentric rings under the phospholipid monolayer.

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