Abstract
Glioma is a highly fatal malignant tumor with a high recurrence rate, poor clinical treatment effect, and prognosis. We aimed to determine the association between single nucleotide polymorphisms (SNPs) of NDRG1 and glioma risk and prognosis in the Chinese Han population. 5 candidate SNPs were genotyped by Agena MassARRAY in 558 cases and 503 controls; logistic regression was used to analyze the relationship between SNPs and glioma risk. We used multi-factor dimensionality reduction to analyze the interaction of 'SNP-SNP'; the prognosis analysis was performed by log-rank test, Kaplan-Meier analysis, and Cox regression model. Our results showed that the polymorphisms of rs3808599 was associated with the reduction of glioma risk in all participants (OR 0.41, p = 0.024) and the participants ≤ 40years old (OR 0.30, p = 0.020). rs3802251 may reduce glioma risk in all participants (OR 0.79, p = 0.008), the male participants (OR 0.68, p = 0.033), and astrocytoma patients (OR 0.81, p = 0.023). rs3779941 was associated with poor glioma prognosis in all participants (HR = 2.59, p = 0.039) or astrocytoma patients (HR = 2.63, p = 0.038). We also found that the key factors for glioma prognosis may include surgical operation, radiotherapy, and chemotherapy. This study is the first to find that NDRG1 gene polymorphisms may have a certain association with glioma risk or prognosis in the Chinese Han population.
Highlights
Glioma is a tumor that originates from neuroectodermal mesenchymal cells and accounts for about 40–50% of brain tumors
Results: our results showed that the rs3808599 was associated with the reduction of glioma risk in all participants (p = 0.024) and the participants ≤40 years old (p = 0.020). rs3802251 may reduce glioma risk in all participants (p = 0.008), the male (p = 0.033) or astrocytoma patients (p = 0.023). rs3779941 was associated with poor glioma prognosis in the all participants (p = 0.039) or astrocytoma patients (p = 0.038)
The Cox hazard proportional regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), and we evaluated the impact of N-myc downstream regulated gene-1 (NDRG1) genotype on the overall survival and progression-free survival of glioma patients
Summary
Glioma is a tumor that originates from neuroectodermal mesenchymal cells and accounts for about 40–50% of brain tumors. It is the most common intracranial malignant tumor [1]. Some studies on the association between genetic polymorphisms and glioma have been reported worldwide [4,5,6,7,8]. These studies have let us to gain some new insights into the pathogenesis of glioma, we have not found an effective, specific and unified method for prevention and treatment. Finding new and effective genetic markers is still very important, which will help us to judge the prognosis of glioma patients early and conduct targeted interventions for treatment
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