Abstract
The aim of this study was to investigate the effect of Na and Ti on thein vitrodegradation and bioactivity in the 58S bioactive glass. The degradation was evaluated through the activation energy of Si ion release from bioactive glasses and the weight loss of bioactive glasses in Tris-HCl buffer solution. Thein vitrobioactivity of the bioactive glasses was investigated by analysis of apatite-formation ability in the simulated body fluid (SBF). The results showed that Na in the 58S glass accelerated the dissolution rate of the glass, whereas Ti in the 58S glass slowed down the rate of glass solubility. Bioactivity tests showed that Na in glass increased the apatite-forming ability in SBF. In contrast, Ti in glass retards the apatite formation at the initial stage of SBF soaking but does not affect the growth of apatite after long periods of soaking.
Highlights
For hard tissue repair, the controlled bioactivity and degradation of materials are required to meet different clinical requirements
Titanium is considered to be harmless in contact with human tissue, and it has ever been used as a nucleating agent in glasses [9]
The chemical compositions are given in Table 1. 58S bioactive glass was prepared using the sol-gel method according to the procedure described by Zhong and Greenspan [10]
Summary
The controlled bioactivity and degradation of materials are required to meet different clinical requirements. A new way to obtain bioactive materials is through the lowtemperature sol-gel method [1]. The rate of surface bone-like hydroxyapatite (HA) formation for the 58S compositions was even more rapid than for melt-derived 45S5 bioglass [3]. This finding offered a potential processing method for molecular and textural tailoring of the biological behavior of a new, third generation of bioactive materials [3]. Few studies have been reported to deal with the influence of Na or Ti substitution on the degradation behavior and bioactivity of the 58S solgel glass
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