Abstract
Due to the increasing number of Candida albicans’ infections and the resistance of this pathogenic fungus to drugs, new therapeutic strategies are sought. One of such strategies may be the use of static magnetic field (SMF). C. albicans cultures were subjected to static magnetic field of the induction 0.5 T in the presence of fluconazole and amphotericin B. We identified a reduction of C. albicans hyphal length. Also, a statistically significant additional effect on the viability of C. albicans was revealed when SMF was combined with the antimycotic drug amphotericin B. The synergistic effect of this antimycotic and SMF may be due to the fact that amphotericin B binds to ergosterol in plasma membrane and SMF similarly to MF could influence domain orientation in plasma membrane (PM).
Highlights
Candida albicans is a microorganism forming part of human microflora, which under immunosuppression causes opportunistic infections (Dadar et al 2018)
Median A600 of cells exposed to all static magnetic field (SMF) zones (N, S, north and south poles (N/S)) was lower than the control (Fig. 1A), the lowest A600 being in the case of exposure to the S/N pole
Maximal A600 was at least 7.2% lower in cells exposed to SMF; minimal A600 was 5% and 3.25% lower in case of exposure to the S and N/S poles, respectively
Summary
Candida albicans is a microorganism forming part of human microflora, which under immunosuppression causes opportunistic infections (Dadar et al 2018). Chronic mucocutaneous candidiasis (CMC) is characterized by infections of the skin, nails, and oral and genital mucosae (Puel et al 2011). After the transition from yeast to hyphal form, C. albicans penetrates the host’s physiological barriers (Richardson et al 2018). C. albicans infections are characterized by increasing resistance to traditional antifungal agents, such as fluconazole. Dariusz Sztafrowski and Jakub Suchodolski contributed to this work. The number of MF applications in medical therapies has been increasing over the last decades and includes magnetotherapy, magnetic stimulation (MS), and transcranial magnetic stimulation (TMS) (Sztafrowski et al 2018)
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