Abstract
The application of polymers for controlled drug delivery is influenced by no toxicity and solubility in different pH mediums. There already are existing pharmaceutical medicaments based on aqueous dispersion of an anionic copolymer methyl acrylate, methyl methacrylate and methacrylic acid. The aim of this work was to synthesise copolymers of methyl methacrylate and methacrylic acid and to estimate the effects of monomers ratio (1:1 and 1:2) on the molecular mass, polydispersity index, and solubility of obtained polymers. Acetone was used as a solvent because both monomers and the initiator azobisisobutyronitrile are soluble in it. FTIR method was used for functional group characterization, the gel permeation chromatography method for average molecular weights and the distribution of molecular weights determinations. High pressure liquid chromatography (HPLC) was applied for the estimation of residual monomers in obtained copolymers. The titration with ethanol solution of NaOH was used for assessing of monomer units in copolymers. The copolymer with the molar ratio of monomers 1:1 was soluble in water bufer with pH values higher then 6, while the copolymer with the molar ratio of monomers 1:2 was soluble in bufer with pH higher then 9.
Highlights
Ekstrakti su filtrirani kroz filter 0,45 μm i korišćeni za HPLC analizu
Content of residual monomer in synthesized copolymers based on different monomer ratio
The time dependence of absorbance value for buffer solution of copolymer obtained with the ratio of monomers in starting reactive mixture 1:2
Summary
UTICAJ MOLSKOG ODNOSA MONOMERA NA SVOJSTVA KOPOLIMERA METILMETAKRILATA I METAKRILNE KISELINE. Primena polimera kao materijala za kontrolisanu raspodelu lekova uslovljena je njihovom netoksičnošću i rastvorljivošću u rastvorima različitih pH vrednosti. Danas postoje farmaceutski polimerni materijali koje se koriste za kontrolisanu raspodelu lekova u vidu vodenih disperzija anjonskih polimera metilakrilata, metilmetakrilata i metakrilne kiseline. Cilj ovog rada je bio da se sintetiše poli(metilmetakrilat-ko-metakrilna kiselina) i da se ustanovi uticaj odnosa monomera na molske mase i rastvorljivost dobijenog kopolimera. Sinteza je urađena u rastvoru sa različitim molskim odnosima monomera metilmetakrilata i metakrilne kiseline (1:1 i 1:2). Cilj ovog rada je bio da se sintetiše kopolimer metilmetakrilata i metakrilne kiseline u rastvaraču acetonu i da se ispita uticaj odnosa monomera (1:1 i 1:2) na rastvorljivost dobijenih polimera u vodenim puferskim rastvorima različitih pH vrednosti. Prema nama dostupnim podacima kopolimeri sa ovim molskim odnosom monomera su već sintetisani, ali u drugom rastvaraču i sa drugim inicijatorom [10,11,12]
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