Abstract
Marital status is viewed as an independent prognostic factor for survival in various cancers. But, little is known about the relationship between marital status and Hodgkin lymphoma (HL) outcomes. To investigate the impact of marital status on the survival of patients with HL, we identified 37884 cases from 1988 to 2013 in the Surveillance, Epidemiology and End Results (SEER) database. The Kaplan–Meier method and multivariate Cox regression model were used for analyzing the influence of marital status on cause-specific survival (CSS). We found patients in widowed group had a higher proportion of women and a higher incidence of older (>60 years) patients; all of these parameters were found to be statistically significant in within-group comparisons. Marital status was demonstrated to be an independent prognostic factor. Widowed individuals were at greater risk of cancer specific mortality relative to other groups. Similar associations in subgroup analyses were observed according to SEER stage. In conclusion, widowed patients suffered survival disadvantages relative to other groups, and marital status had significant prognostic value in HL.
Highlights
Hodgkin lymphoma (HL) is a rare cancer of the lymphatic system [1]
We found patients in widowed group had a higher proportion of women and a higher incidence of older (>60 years) patients; all of these parameters were found to be statistically significant in withingroup comparisons
It accounts for 10% of all lymphomas and less than 1% of all cancers diagnosed in United States (US) annually [2]
Summary
Hodgkin lymphoma (HL) is a rare cancer of the lymphatic system [1]. It accounts for 10% of all lymphomas and less than 1% of all cancers diagnosed in United States (US) annually [2]. In the 1960s, the 5-year survival rate for HL was less than 10% [4]. Because of advances in treatment, survival has improved; the reported 5-year survival rate for patients with HL during the years 20002004 was 85.2% [5]. There are differences in patient survival related to the tumor’s histology and its stage at diagnosis
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