Abstract
We investigated the influence of two cations (manganese in Mn sulfate and lead in Pb acetate) on the vasodepressant effect of an angiotensin converting enzyme (ACE) inhibitor, lisinopril (SynoprylR Eczacibasi). We worked on 6 series of 6 adult male Wistar rats each, bred in the same laboratory conditions and identically fed. We determined the animal blood pressure (BP) by a non invasive technique using a Hugo Sachs S-2 Sphigmomanometer. We measured the BP just before the substances administration, at 2, 4 and 7 hours after the administration. We also determined the plasmatic concentrations of Mn and Pb (using a atomic absorption spectroscopy method) at 2, 4 and 7 hours. The obtained data were statistically interpreted by the means of “t” test. Our data show that Mn sulfate moderately (but statistically significant) increases the BP 7 hours after the administration and it shortens the duration of vascular effect of lisinopril. Pb acetate doesn’t significantly modify the BP and, when associated with lisinopril, slightly decreases the Lis vasodepressant effect at 2-7 hours after administration. We consider that ACE inhibitors vascular effect could be reduced by the enhanced plasmatic level of Mn and Pb.
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