Abstract
Abstract The article presents the results of research on the effect of magnetic hyperthermia performed on agar gel samples containing magnetite nanoparticles coated with dextran polymers for different molar weight M (150 kDa, 70 kDa, and 40 kDa). Regardless of the difference in molar dextran weights, these samples differed in a mass concentration of nanoparticles in the ferrogel C0 (1.602 mg/cm3, 2.506 mg/cm3, 3.311 mg/cm3, and 4.218 mg/cm3). In the case of the highest magnetic field value H (20 kA·m−1), the specific loss power SPL reaches 70 W·g−1 for nanoparticles with 150 kDa dextran at a concentration of nanoparticles C0 = 1.602 mg/cm3. An oscillating magnetic field with an amplitude up to 20 kA·m−1 and a frequency of 357 kHz was used in the study.
Highlights
The use of magnetic nanoparticles in medicine is well known in magnetic hyperthermia treatments for the destruction of an oncological tumor
An agar gel containing magnetite nanoparticles was placed inside the coil
In order to effectively heat the body soft tissues, it is assumed in the literature [4] that this coefficient should have a minimum value of 100 mW·g−1. Another parameter is the specific loss power (SLP), which allows assessing the amount of thermal power that is released by 1 g of magnetic material contained in a magnetic liquid, in a ferrogel or in the soft tissues of the body
Summary
The use of magnetic nanoparticles in medicine is well known in magnetic hyperthermia treatments for the destruction of an oncological tumor. In this case, magnetite nanoparticles with a diameter of several nanometers are introduced into the tumor and an oscillating magnetic field with a frequency of several hundred kilohertz is applied. The tumor area with cancerous cells reaches a temperature of about 42–43 °C, which is several degrees higher than the body's physiological temperature. These diseased cancer cells are less resistant to overheating than healthy cells and are destroyed. Due to the similar properties of the agar gel to the soft tissues of the body, the conditions of the in vitro experiment are similar to in vivo [17,18]
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