Abstract
Platelet aggregation in platelet-rich plasma, induced by adenosine diphosphate (ADP) collagen, thrombin, adrenalin and ristocetin, is inhibited by lithium ions. Calcium will enhance the aggregation induced by all these agents, except ristocetin. The aggregation of ristocetin-induced, formalin-fixed platelets is inhibited by lithium when the platelets are resuspended in saline or plasma. Lithium levels within the approved therapeutic range are sufficient to affect both ADP and ristocetin-induced platelet aggregation.
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