Abstract
The physical stability of the four liposomal systems was determined on storage at 4 and 25°C over a 6-month period. A correlation of the mean volume diameter, zeta potential and pH lead to the conclusion that stability follows the order of egg lecithin (PC)/cholesterol (CH)/stearylamine (SA) < PC/CH/phosphatidylserine (PS) < bovine brain ceramides (CM)/CH/palmitic acid (PA)/CS < PC/CH/cholesteryl sulphate (CS) at 4°C, as well as at 25°C, after a 6-month storage period. Large unilamellar vesicles (REV) proved to be superior to multilamellar liposomes (MLV) and dehydration/rehydration liposomes (DRV) systems as far as physical stability was concerned. Instability was exaggerated in the systems stored at 25°C as compared to storage at 4°C.
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