Abstract
Objective To explore the effects of lidocaine on the expressions of tumor necrosis factor-a (TNF-α) and intercellular adhesion molecule-1 (ICAM-1) in intestines subjected to ischemia/reperfusion (I/R) injury.Methods In this study,48 Sprague-Dawley (SD) rats aged 4 weeks old were randomly divided into 3 groups according to their treatment.In the I/R group,the abdominal cavity of the rats was opened,and the intestinal I/R injury was induced by 60 minutes' superior mesenteric artery occlusion followed by reperfusion for 30 min,60 min,90 min and 120 min.In the lidocaine treatment group,the rats were subjected to intestinal I/R injury,and administered with Lidocaine by femoral vein injection before reperfusion.The sham operated rats were only performed laparotomy.The intestines were harvested for immunohistochemical study to explore the expressions of TNF-α and ICAM-1.Results The sham operated rats had low TNF-α and ICAM-1 expressions.After I/R injury,the expressions of TNF-α and ICAM-1 in intestine were significantly elevated,but Lidocaine treatment inhibited the I/R induced up-regulation of TNF-α and ICAM-1 (all P＜0.05).The intestinal expression of ICAM-1 remained unchanged in 30 min and 60 rnin after I/R (all P＞0.05).Conclusions Lidocaine down-regulates the expressions of TNF-α and ICAM-1 in intestine after ischemia/reperfusion injury in young rats. Key words: Reperfusion injury; Lidocaine; Tumor necrosis factor-alpha; Cell adhesion molecules
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