Abstract
Spontaneous uterine activity and reactivity to oxytocin, naproxen and PGF 2α were studied in vitro in 80 rats, which for 2–8 weeks had been exposed to different concentrations and combinations of Pb 2+, Zn 2+ and Cu 2+ in their water supply or had been given clean water for control. In rats given only Pb 2+ in concentrations of 1000 and 500 ppm for 6 weeks the uterine activity was significantly increased, whereas in groups given the other ions alone, or Pb 2+ for 6 weeks followed by 2 weeks of clean water or Zn 2+ or Cu 2+ no change was observed. The responses to the oxytocin, naproxen and PGF 2α did not differ. These results suggest that contamination with lead ions might be one of the etiological factors involved in conditions with increased uterine activity.
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