The influence of juvenile capsaicin desenzitization on different sensory processes

Abstract

Event Abstract Back to Event The influence of juvenile capsaicin desenzitization on different sensory processes Gábor Tuboly1*, Gabriella Kékesi1, Gabor Adam1, Gyorgy Benedek1 and Gyöngyi Horváth1 1 Department of Physiology, University of Szeged, Hungary Introduction: Several data suggest that neonatal versus adult capsaicin desensitization leads to different phenotypes in some respects. The goal of this study was to reveal the effects of high dose capsaicin treatment on different parameters (pain sensitivity, thermoregulation, visceral function) in young but not neonate animals. Methods: 21 days old male Wistar rats, after weaning, were injected for 4 days with capsaicin in increasing doses of 10, 20 50 and 100 mg/kg intraperitoneally. Control animals received physiological saline. The animals were followed up for 3 months and we determined the body weight, the blepharosmasm and paw wiping reflex of the eye exposed to diluted capsaicin, changes in acute and inflammatory pain sensitivity, volume of the urinary bladder and body temperature. Results: The body weight of capsaicin-treated animals decreased temporarily compared to the control group. Capsaicin-treated animals had complete abolishment of eye-wipe responses and blepharospasm, suggesting that desensitization prevented the painful effects of capsaicin eye drops. Both heat and mechanical acute pain sensitivity augmented while pain threshold in inflamed limbs diminished. Ultrasound examination of urinary bladder revealed that the volume was significantly larger compared to untreated animals. Disturbance in thermoregulation has been also observed since desensitized rats had higher body temperature. Our results suggest that juvenile capsaicin desensitization produced sustained changes in several physiological parameters, and these changes are similar to alterations observed after adult capsaicin desensitization. This work was supported by the National Research and development Office, Hungary (OMFB-0066/2005/DNT) and a Hungarian Research Grant (OTKA, K60278). Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Pathophysiology and neurology - non-degenerative disorders Citation: Tuboly G, Kékesi G, Adam G, Benedek G and Horváth G (2009). The influence of juvenile capsaicin desenzitization on different sensory processes. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.042 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Feb 2009; Published Online: 27 Feb 2009. * Correspondence: Gábor Tuboly, Department of Physiology, University of Szeged, Szeged, Hungary, corp120@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gábor Tuboly Gabriella Kékesi Gabor Adam Gyorgy Benedek Gyöngyi Horváth Google Gábor Tuboly Gabriella Kékesi Gabor Adam Gyorgy Benedek Gyöngyi Horváth Google Scholar Gábor Tuboly Gabriella Kékesi Gabor Adam Gyorgy Benedek Gyöngyi Horváth PubMed Gábor Tuboly Gabriella Kékesi Gabor Adam Gyorgy Benedek Gyöngyi Horváth Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.