Abstract
The influence of indole-2,3 dione (isatin) on particulate guanylyl cyclase (GC) from rat heart membranes was investigated in the presence of adenylylimidodiphosphate (AMP-PNP). The latter activated GC in a concentration-dependent manner and 100 μM isatin abolished this effect. The IC 50 value, 2 μM, for the inhibition of stimulation of GC induced by 50 μM AMP-PNP, was close to the upper physiological level of isatin. These results indicate that isatin may interact with GC independently of its regulation by natriuretic peptides.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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