Abstract
Affliation. Federal state budgetary educational institution of higher education «Kursk state medical university» Ministry of healthcare Russian Federation.Our aim is the relevance of the research topic is conditioned by the wide spreading of the periodontitis among effcient population. The purpose of investigation – the research of the influence of indolicidin analogues N7 and N8 on the content of connective tissue matrix and prooxidant-antioxidant balance in the periodontium in the periodontitis. Methods: periodontitis was simulated according to the method supposed by Volozhin A.I. and Vinogradova S.I. (1990). The animals were withdrawal from the experiment in the 7, 14 and 21 days after the removal of the thread. The content of oxyproline, glycosaminoglycans malonic aldehyde, acylhydroperoxides, catalase activity were determined in the periodontium tissue. Indolicidin analogues N7 and N8 were injected intraperitoneally within 7 days after the removal of the thread.Results. the increase of the concentration of lipid peroxidation metabolites, the decrease of the content of free and bound oxyproline, glycosaminoglycans, catalase activity. Both indolicidin analogues had two-phase influence on the concentration of malonic aldehyde and acylhydroperoxides: the increase on the 7 day and the decrease on the 21 one; increased the concentration of free and bound oxyproline, glycosaminoglycans.Summary. Periodontitis development is accompanied by the decrease of the content of free and bound oxyproline, glycosaminoglycans, lipid peroxidation activation, the drop of catalase activity in the periodontium tissue. The investigated indolicidin analogues had two-phase action on the content of the lipid peroxidation metabolites in the periodontium: the increase on the 7 day and the decrease on the 21 one; increased the concentration of free and bound oxyproline, glycosaminoglycans, stimulated the catalase activity.
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