Abstract
Objective: study of associations between VDR gene rs1544410 and rs10735810 polymorphisms, MCM6 gene rs4988235, CALCR gene rs1801197 one and ibandronate efficacy in women with postmenopausal osteoporosis.Materials and methods: 117 women with postmenopausal osteoporosis were examined for 12 months in the dynamics of treatment with ibandronate. Evaluation of therapy effectiveness was based on indicators of increase in bone mineral density in L1-L4 lumbar vertebrae, as well as left and right femurs.Results: An association of GG genotype of VDR gene rs1544410 polymorphism with low growth rates of mineral density of L1-L4 lumbar vertebrae (3,41 ± 0,60 % versus 5,51 ± 0,78 % in other women; р = 0,036) was established. The effect of other studied polymorphisms (rs10735810 of VDR gene, rs4988235 of MCM6 gene, rs1801197 of CALCR gene) on treatment effectiveness was not found.Conclusion: it is advisable to use obtained results when developing personalized regimens for antiresorptive therapy for women with postmenopausal osteoporosis.
Highlights
Оригинальные статьиЦель: изучить ассоциации полиморфизмов rs1544410 и rs10735810 гена VDR, rs4988235 гена MCM6 и rs1801197 гена CALCR с показателями эффективности применения ибандроната у женщин с постменопаузальным остеопорозом
Постменопаузальный остеопороз (ОП) — широко распространенное среди женщин постменопаузального возраста заболевание, характеризующееся высокой хрупкостью костной ткани и склонностью к развитию низкоэнергетических переломов
Simrok participated in the development of the concept and design
Summary
Цель: изучить ассоциации полиморфизмов rs1544410 и rs10735810 гена VDR, rs4988235 гена MCM6 и rs1801197 гена CALCR с показателями эффективности применения ибандроната у женщин с постменопаузальным остеопорозом. Результаты: установлена ассоциация генотипа GG полиморфизма rs1544410 гена VDR с низкими показателями прироста минеральной плотности в поясничных позвонках L1-L4 (3,41 ± 0,60 % против 5,51 ± 0,78 % у остальных женщин; р = 0,036). Objective: study of associations between VDR gene rs1544410 and rs10735810 polymorphisms, MCM6 gene rs4988235, CALCR gene rs1801197 one and ibandronate efficacy in women with postmenopausal osteoporosis. Results: An association of GG genotype of VDR gene rs1544410 polymorphism with low growth rates of mineral density of L1-L4 lumbar vertebrae (3,41 ± 0,60 % versus 5,51 ± 0,78 % in other women; р = 0,036) was established. Conclusion: it is advisable to use obtained results when developing personalized regimens for antiresorptive therapy for women with postmenopausal osteoporosis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
