Abstract
To explore the role and mechanism of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) formed in non-alcoholic fatty liver disease. By using oleic acid stimulation L-O2 to induce fatty liver model, we observe the changes of relevant biochemical indexes by interference of IGF2BP3 gene expression, to investigate the change of the formation of lipid droplets through oil red O staining. Compared with control cells, in fatty liver cell model group, IGF2BP3 expression level increased significantly (P<0.05). As to the biochemical indicators: alanine transaminase (ALT), aspertate aminotransferase (AST), triglycerides, and tumor necrosis factor-α, interleukin 6 levels were significantly increased (all P<0.05). But, after interference of IGF2BP3 gene expression, ALT, AST, triglycerides, tumor necrosis factor-α, and interleukin 6 levels were significantly decreased (all P<0.05). Fatty droplet formation infatty liver cells were dramatically improved. IGF2BP3 may participate in the formation and development of non-alcoholic fatty liver disease.(Chin J Endocrinol Metab, 2015, 31: 1060-1063) Key words: IGF2BP3; Non-alcoholic fatty liver disease; Interference
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
