Abstract
PurposeThis study aims to explore the incidence of hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and the influence of hypoglycemia on the specific quality of life in T2DM patients.MethodsIt was a comparative cross-sectional study consisting of 519 T2DM patients in Xi'an, China and patients were investigated by self-reported hypoglycemia and specific quality of life questionnaires from September 2019 to January 2020. Descriptive analysis, t-test, Chi-square test, hierarchical regression analysis and stepwise multiple regression analysis were applied to assess the influence of hypoglycemia on the specific quality of life.ResultsThe incidence of hypoglycemia in T2DM patients was 32.18%. The mean score of specific quality of life in diabetes without hypoglycemia was 57.33 ± 15.36 and was 61.56 ± 17.50 in those with hypoglycemia, which indicated that hypoglycemia had a serious impact on the quality of life of diabetics (t = − 5.172, p = 0.000). In the Univariate analysis of specific quality of life, age, education background, marital status, living status, duration of diabetes, monthly income per capita were independent and significant factors associated with specific quality of life of two groups of T2DM patients (p < 0.05). In the hierarchical regression analysis, the duration of the diabetes more than 11 years and the frequency of hypoglycemia more than 6 times in half a year entered the equation of specific quality of life of 519 diabetics respectively (p < 0.001). In multiple linear regression analysis, age, marital status and income all entered the regression equation of quality of life of the two groups (p < 0.05).ConclusionHypoglycemia will have a serious impact on the quality of life of T2DM patients. In order to improve the living quality in diabetics, effective measurements should be taken to strengthen the management of blood glucose and to avoid hypoglycemia.
Highlights
As an increasingly common chronic disease, the incidence rate of Chinese diabetes is the highest in the world [1, 2]
As the country with the largest number of diabetic patients, China should underline the treatment of patients, and the impact of the symptoms caused by diseases on their life
Characteristics of the participant A total of 519 type 2 diabetes mellitus (T2DM) patients participated were included in this study, 352 of whom had no hypoglycemia, while 167 had hypoglycemia before
Summary
As an increasingly common chronic disease, the incidence rate of Chinese diabetes is the highest in the world [1, 2]. Diabetes causes physical damage to life span, and has a serious impact on individual social interaction and psychological health, which impede social and economic development [5, 6]. Diabetics with hypoglycemia are more likely to suffer from anxiety, depression and other psychological problems, which will affect the control of blood sugar and treatment effect [17]. As the country with the largest number of diabetic patients, China should underline the treatment of patients, and the impact of the symptoms caused by diseases on their life. To further explore the effect of hypoglycemia on the quality of life of T2DM patients and its’ influencing factors in China, we adopt the method of comparative cross-sectional study and quantitative analysis so as to provide reference for the comprehensive prevention and treatment of diabetes
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