THE INFLUENCE OF HYPODYNAMY ON THE QUALITY OF THE FEMUR BONE TISSUE IN THE EXPERIMENT

Abstract

Femur fractures make up 10-12% in the total number of all traumatic injuries of the human bone system. Among the reasons of the high frequency of femur fractures, various authors point out, in addition to anatomical features, a decrease in the quality of bone tissue caused by hypodynamia. The purpose of our work was to fi nd out the changes in the quality of bone tissue that develop in diff erent areas of the proximal part of the femur on the background of forced hypodynamia.The study was performed on 10 white outbredsexually mature male rats aged 3.0-3.5 months and with weigh 180.0-200.0 g. Forced hypodynamia was modeled by immobilizing the hind limbs with a plaster cast of the coxite type (with metal wire reinforcement), with full restriction of movement in hip and knee joints. The observation period was 4 weeks. The density of bone tissue in the area of the head, neck, greater trochanter and the proximal area of the diaphysis of the femur was determined by radiovisiography.It was established that the bone tissue of the greater trochanterhas has the highest density indicators (156.8±14.87), slightly lower has the head (143.92±13.07 CGU) and the proximal part of the diaphysis of the femur (136.32±19.68 CGU) and the lowest has the neckof the femur (131.28±12.86 CGU).On the background of the absence of changes in the hip and knee joints and in the structure of the bone tissue of the femur according to radiography data, after four weeks of forced hypodynamia, the density of the bone tissue of the head of the femur and the greater trochanter decreased to 140.08+9.84 CGU and 149.97±16.18 CGU, respectively, the density of the bone tissue of the proximal part of the diaphysis of the femur increased to 143.73±17.52 CGU, and the density of the bone tissue of the neck of the femur remained at the same level as in the intact rat, amounting to 131.04±9.16 CGU.