Abstract
An intravenous injection of fresh rabbit blood into cats caused a circulatory shock appearing in three distinct phases. Using the blood-bathed organ technique it was found that the first hypotensive phase was correlated with an appearance of histamine and kinin-like substances in mixed venous blood the second hypertensive phase was associated with catecholaminemia, while the last fatal hypotensive phase was accompanied by a release of prostaglandin-like substances. Indomethacin 20 mg/kg i.v. or hydrocortisone 50 mg/kg i.v. abolished the release of prostaglandin-like substances, prevented the fatal hypotension and thereby protected cats against immediate death. Pretreatment with propranolol 0.5 mg/kg and phenoxybenzamine 1 mg/kg i.v. abolished the second and the third phases of the shock, but did not influence the survival times of the animals. It is concluded that pharmacological inhibition of prostaglandin release either by steroidal or non-steroidal anti-inflammatory drugs protects against circulatory shock, which is induced by an injection of foreign species blood.
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