Abstract
This study evaluated the influence of human chorionic gonadotropin on hormonal and haematological profile of postpubertal male albino rats exposed to chronic oral administration of alcohol. Twenty-four mature male albino rats were assigned to four groups (n=6). Group A was the control, given distilled water, Group B was given 30% ethanol (8 ml/kg) orally 3 times a week, Group C was given human chorionic gonadotropin (HcG) (50 IU/kg) subcutaneously 3 times a week and Group D was given HcG (50 IU/kg) subcutaneously + 30% ethanol (8 ml/kg) orally 3 times a week. The study was for 10 weeks, and hormonal profile and haematology were determined. The follicle stimulating hormone of Group B decreased significantly (P<0.05) when compared to Groups A, C and D. The luteinizing hormone was significantly lower (P<0.05) in Group B when compared to Groups A, C and D. The testosterone level was significantly higher (P<0.05) in Group D when compared to Groups A, B and C. The results obtained from haematology indicated that haemoglobin concentration of Group B was significantly lower (P<0.05) when compared to Groups A, C and D. Ethanol significantly reduced (P<0.05) platelets when compared to Groups A, C and D. There was a significant reduction (P<0.05) in the neutrophils and lymphocytes in Group B when compared to Groups A, C and D. The study showed that HcG improves the level of male hormones and haematology in postpubertal albino rats exposed to chronic alcohol administration.
Highlights
Male hormones play an organizational role, priming the body to behave in a certain way once puberty begins, and an activational role, referring to changes in hormones during puberty that trigger behavioral and physical changes (Mooradian et al, 1987)
This study evaluated the influence of human chorionic gonadotropin on hormonal and haematological profile of postpubertal male albino rats exposed to chronic oral administration of alcohol
The results obtained from hormonal assay (Figure 1) indicated a significant decrease (P
Summary
Male hormones play an organizational role, priming the body to behave in a certain way once puberty begins, and an activational role, referring to changes in hormones during puberty that trigger behavioral and physical changes (Mooradian et al, 1987). At the onset of puberty, the hypothalamus secrets high pulses of gonadotropin-releasing hormone (GnRH). The pituitary gland releases follicle stimulating hormone (FSH) and luteinizing hormone (LH) into the male system (Mooradian et al, 1987). Stimulates the Sertoli cells, which help to nourish the sperm cells that the testes produce, to facilitate spermatogenesis (Ronko and Llanos, 2000). Luteinizing hormone stimulates the interstitial cells, called Leydig cells, to produce and release testosterone into the blood (Petering and Brooks, 2017). Received in revised form: 24 Nov 2020.
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