Abstract
The dissolution of hyaluronan in water leads to its degradation, and as a result its molecular weight decreases. The degradation of hyaluronan is mainly influenced by temperature, solution composition, and also its pH. This study describes the influence of Hofmeister series ions on hyaluronan behaviour and hyaluronan film swelling by solutions of these ions. It was found that Hofmeister ions show lyotropic effects influencing the entanglement of hyaluronan coils and their expansion from solid polymer films into swollen gel state. The hydrophobic and hydrophilic interactions in the structure of hyaluronan macromolecules are represented by the mutual diffusion coefficient D(c), the mean mutual diffusion coefficient Ds, the expansion work of coil swelling RAδ,s, the activation enthalpy of diffusion connected with swelling HD,s and kinematic viscosity of hyaluronan-ions solutions ν.
Highlights
In 1934 Meyer and Palmer described a procedure for isolation of a novel glycosaminoglycan from the vitreous humor of bovine eyes [1]
Numerous ideas have been offered for applying hyaluronan in different areas and nowadays, many of them are used in medicine, pharmacology or in cosmetics
It is very useful to study the influence of any ions present in hyaluronan solutions on the secondary and tertiary structure of this polysaccharide
Summary
In 1934 Meyer and Palmer described a procedure for isolation of a novel glycosaminoglycan from the vitreous humor of bovine eyes [1]. It is very useful to study the influence of any ions present in hyaluronan solutions on the secondary and tertiary structure of this polysaccharide. Ions of the Hofmeister series have a significant effect on the solubility of macromolecular substances and on the stability of their respective secondary, tertiary and quaternary structures.
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