Abstract
In this work we presented two-, three-, and four-substrate static combinatorial libraries (SCLs) obtained via macrocyclization of BINOL-based dimethyl ester and five α,ω-diaminoethers of varying lengths. We investigated the distribution of macrocyclic products and measured the conversion of ester, comparing the results under atmospheric pressure to those obtained under high pressure conditions. Overall, we found that pressurization had a great impact on the proportions between macrocyclic products, promoting diamides with smaller macrocyclic cavities, i.e. those formed with shorter diaminoethers. Furthermore, static combinatorial chemistry (SCC) approach allow us to receive various potential macrocyclic receptors in single experiment.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
