Abstract
We used a genetic system of the leg-arista-wing complex/TBP related factor 2 (lawc/Trf2) gene complex as a suitable model for in vivo study of the relationship between divergent overlapping genes. We established lines of transgenic fruit flies carrying constructs capable of expressing hairpin RNA directed at post-transcriptional suppression of the lawc mRNA by way of RNA-interference. The attempt to artificially suppress lawc-transcripts caused a rise in the level of expression of the lawc gene by several times. It is shown that change in the concentration of lawc-transcripts can affect the concentration of Trf2-transcripts. Possible mechanisms of regulation of expression of the overlapping genes studied are discussed.
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