Abstract
Treatments of rabbits with gonadotropins in vivo failed to produce demonstrable stimulation of the conversion of [4-14C]cholesterol to [14C]testosterone by homogenate of testis. Short-term treatment (1–12 h) of hypophysectomized rats with human chorionic gonadotropin or interstitial cell-stimulating hormone also failed to increase the conversion of cholesterol to androgens by homogenate of testis. However, 24 h after a single injection of human chorionic gonadotropin or interstitial cell-stimulating hormone an increase in the conversion of cholesterol to androgens by homogenate of testis from hypophysectomized rats was observed.
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