Abstract
1. 1. The influence of Glc-1,6- P 2 on hepatic and red blood cell pyruvate kinase (ATP: pyruvate phosphotransferase, EC 2.7.1.40) is quite similar to that of Fru-1,6- P 2. The hexose diphosphates can replace each other in stimulating pyruvate kinase; after maximal stimulation by one of the compounds, the other is not capable of further stimulation. 2. 2. The regulatory role of Fru-1,6- P 2 on the activity of pyruvate kinase is discussed in view of the results obtained.
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