Abstract
Purpose: To establish the influence of glomerular filtration rate (eGFR) on KS values assessed by ARFI elastography. Methods: Our study included 88 subjects: 50 “normal” subjects (56.8%) (hospitalized patients for various diseases with normal renal ultrasonography, normal serum creatinine and blood nitrogen urea, without proteinuria or hematuria) and 38 (43.2%) patients with various kidney diseases. The mean age of subjects was 57.1 ± 13.6 years, 37.5% being women and 62.5% men. Five valid ARFI measurements were performed in the parenchyma of the each kidney with the subjects in left or right lateral decubitus, median values were calculated and expressed in meters/second (m/s). The eGFR was estimated using the MDRD4 formula. Results: Valid ARFI measurements were obtained in all subjects in the right kidney and in 97.7% of cases in the left kidney. The mean ARFI values obtained in the right and left kidney were similar in “normal” kidneys and also in kidneys with pathology: 2.21 ± 0.80 m/s vs. 2.16 ± 0.75 m/s, p = 0.35 and respectively 2.08 ± 0.77 m/s vs. 2.02 ± 0.86 m/s, p = 0.62. Because the mean value of KS was similar in the right and left kidney in both “normal” subjects and those with kidney pathology, the chose to study the influence of eGRF on KS values obtained in the right kidney. The mean ARFI values obtained in the right kidney according to the eGFR rate were: > 90 ml/min/1.73 m2 (35 subjects) -2.27 ± 0.79 m/s; 30 – 89 ml/min/1.73 m2 (45 subjects) -2.16 ± 0.78 m/s and 90 ml/min/1.73 m2 (2.27 ± 0.79 m/s) vs. < 30 ml/min/1.73 m2 (1.62 ± 0.58 m/s), p = 0.03 and respectively 30 – 89 ml/min/1.73 m2 (2.16 ± 0.78 m/s) vs. < 30 ml/min/1.73 m2 (1.62± 0.58 m/s), p = 0.04. Conclusion: KS values obtained by ARFI elastography were significantly lower in patients with moderate and severe alteration of kidney function (eGFR< 30 ml/min) as compared with subjects with normal renal function or those with mild alteration of renal function.
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