The influence of glicerides oil phase on O/W nanoemulsion formation by pic method

Małgorzata Jaworska,Jan Ogonowski,Elżbieta Sikora

doi:10.3311/ppch.7299

Abstract

The aim of this work was preparation and characterization of nanoemulsions containing Caprylic/Capric Triglyceride, Caprylic/Capric/Linoleic Triglyceride and Caprylic/Capric/Succinic Triglyceride as the oil phase. Stable emulsion system was obtained by using Polisorbate 40 as emulsifier and n-buthanol as cosurfactant. The formulations were prepared by phase inversion composition method (PIC), one of the low energy emulsification method, by stepwise water addition to the mixture of oil and surfactant, at room temperature(25oC).The mixture was stirred by using a magnetic stirrer. The type of the emulsions was confirmed by conductivity measurement. The particles size distribution was analyzed by Dynamic Light Scattering measurement technique using Zetasizer Nano ZS (Malvern Instruments, UK). Rheological studies of the systems were carried out using Brookfield Rheometer Model -R/SPlus. The obtained results showed that properties of the emulsions depend on kind of the oil phase. It was observed that the increase of oil phase polarity causes the increase of the particle size of internal phase.

Highlights

1 Introduction Nanoemulsions are the novel class of emulsions with high degree of inert phase dispersion.Particles of nanoemulsions are too small to scatter visible light, that makes them optically transparent or translucent
The aim of this work was preparation and characterization of nanoemulsions containing as the oil phase Caprylic/Capric Triglycerides, Caprylic/Capric/Linoleic Triglycerides and Caprylic/Capric/Succinic Triglycerides
4 Conclusions The obtained results showed that properties of the emulsions depend on kind of the oil phase

Summary

Introduction

Nanoemulsions are the novel class of emulsions with high degree of inert phase dispersion.Particles of nanoemulsions are too small to scatter visible light (droplet size are in the range between 20 - 200 nm), that makes them optically transparent or translucent. From chemical point of view they are esters of glycerin and fatty acids They usually applied in skin care products as emollients, lipophilic vehicles, skin permeation enhancers and solubilisers. Their properties strongly depend on chemical composition [7,8,9]. Caprylic/capric triglycerides are fully saturated triglycerides, with excellent emolliency and good user properties, e.g. easy spreading orno occlusive feeling. It is entirely derived from vegetable resources and offers a stable alternative to mineral or vegetable oil.

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