Abstract

This records an effort to apply the principle of forced diuresis or histolavage to the treatment of experimental poisoning with diphtheria toxin. As certain of the bacterial poisons are known to be capable of excretion in considerable amounts by way of the urine, a great acceleration of diuresis might appear to be a more rational procedure in the case of certain infections than in the case of poisoning with heavy metals. Diphtheria toxin was selected because it is sufficiently stable to permit of standardization. The work is reported for the sake of completeness along with that on glaucoma, mercuric chlorid poisoning, etc., since it serves to amplify our knowledge of what may or may not be accomplished by salt and sugar diuresis in general. 1 TECHNIC The same general plan was followed as in the mercuric chlorid work. 2 The diphtheria toxin was a stable product 2 years old. The

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