Abstract
The intraperitoneal injection of the well known monooxygenase inducers (phenobarbital, β-naphtoflavone, pregnenolone-16α-carbonitrile, benzo(a)-pyrene, methylcholanthrene) elicits a net decrease in the specific binding of estradiol to its cytosol receptor in female rat livers. Amongst the five chemicals tested, only phenobarbital did not exhibit such a phenomenon, but caused a slight increase. This observation was neither due to a competitive inhibition by these compounds, nor to an enhanced metabolism of [ 3H]-estradiol. Moreover, when this effect was produced by polycyclic hydrocarbons, it was inversely correlated to the activity of aryl hydrocarbon hydroxylase, induced by these same chemicals.
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